Title : Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase.

Pub. Date : 1993 Oct

PMID : 7691579






2 Functional Relationships(s)
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1 Thus, 10 mM nicotinamide decreased rIL-1 beta-induced nitrite formation by 30%, 20 mM by 60%, and 50 mM by 90%. Niacinamide interleukin 1 beta Rattus norvegicus
2 The highest concentration of nicotinamide also prevented rIL-1 beta-induced iNOS mRNA, an effect associated with inhibition of total protein biosynthesis. Niacinamide interleukin 1 beta Rattus norvegicus