Pub. Date : 1993 Jul
PMID : 7686736
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bradykinin receptors and signal transduction pathways in human fibroblasts: integral role for extracellular calcium. | Calcium | kininogen 1 | Homo sapiens |
| 2 | Bradykinin receptors have been identified in human gingival fibroblasts; the primary signal transduction pathways and their dependence on calcium have been characterized. | Calcium | kininogen 1 | Homo sapiens |
| 3 | Binding data revealed a calcium-independent binding of bradykinin to the cell membrane with a receptor density of 25,000 receptors per cell and a Kd of 1.6 nM. | Calcium | kininogen 1 | Homo sapiens |
| 4 | Together these results demonstrate the presence of bradykinin receptors in human gingival fibroblasts; these receptors are coupled to signal transduction mechanisms involving the PLC, PLA2, and tyrosine kinase effector systems, all of which require extracellular calcium to achieve maximal activation. | Calcium | kininogen 1 | Homo sapiens |