Title : Interleukin 1 activation of the AP-1 transcription complex in murine T cells is regulated at the level of Jun B protein accumulation.

Pub. Date : 1995 Aug

PMID : 7675040






2 Functional Relationships(s)
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1 We found that IL-1 + TPA-treated cells contain significantly higher Jun B protein levels than cells treated with TPA alone. Tetradecanoylphorbol Acetate jun B proto-oncogene Mus musculus
2 Thus, the stimulation of AP-1-mediated gene expression by IL-1 in EL4 cells is due to the promotion of Jun B protein accumulation that, in turn, facilitates Jun B heterodimerization with TPA-induced Fra-1 protein, thereby forming an active AP-1 complex. Tetradecanoylphorbol Acetate jun B proto-oncogene Mus musculus