Pub. Date : 1995 Sep 8
PMID : 7673143
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By binding to clusters of PIP2, profilin is able to inhibit the hydrolysis of PIP2 by phospholipase C gamma 1 (PLC gamma 1). | Phosphatidylinositol 4,5-Diphosphate | phospholipase C gamma 1 | Homo sapiens |
| 2 | By binding to clusters of PIP2, profilin is able to inhibit the hydrolysis of PIP2 by phospholipase C gamma 1 (PLC gamma 1). | Phosphatidylinositol 4,5-Diphosphate | phospholipase C gamma 1 | Homo sapiens |
| 3 | By binding to clusters of PIP2, profilin is able to inhibit the hydrolysis of PIP2 by phospholipase C gamma 1 (PLC gamma 1). | Phosphatidylinositol 4,5-Diphosphate | phospholipase C gamma 1 | Homo sapiens |
| 4 | By binding to clusters of PIP2, profilin is able to inhibit the hydrolysis of PIP2 by phospholipase C gamma 1 (PLC gamma 1). | Phosphatidylinositol 4,5-Diphosphate | phospholipase C gamma 1 | Homo sapiens |
| 5 | When tested for their relative abilities to inhibit the hydrolysis of PIP2 by PLC gamma 1, most of the mutants were indistinguishable from wild-type profilin. | Phosphatidylinositol 4,5-Diphosphate | phospholipase C gamma 1 | Homo sapiens |
| 6 | Taken together with the finding that mutating residue 88 resulted in decreased inhibition of PLC gamma 1 activity, these data provide strong evidence that this region of human profilin represents an important binding site for PIP2. | Phosphatidylinositol 4,5-Diphosphate | phospholipase C gamma 1 | Homo sapiens |