Title : In vitro binding of [3H]nimodipine and [3H]CGS-19755 to rat brain in focal cerebral ischemia.

Pub. Date : 1995 Jul

PMID : 7672038






2 Functional Relationships(s)
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1 [3H]Nimodipine binding to the nonischemic hemisphere was characterized by one binding site with regional binding affinity (KD) estimates ranging from 221 to 482 pM and maximal binding site densities (BMAX) ranging from 13.2 (9.6-17.5) pmol/g tissue (estimate and 95% confidence interval) in CA1 to 32.5 (26.5-39.9) pmol/g tissue in dentate. Tritium carbonic anhydrase 1 Rattus norvegicus
2 [3H]CGS-19755 binding to the nonischemic hemisphere was characterized by KD estimates ranging from 59 to 97 nM and BMAX values ranging from 143 (108-192) pmol/g tissue in cortex to 569 (515-641) pmol/g tissue in CA1. Tritium carbonic anhydrase 1 Rattus norvegicus