Title : gamma-interferon production in atopic dermatitis shows differential modification by phosphodiesterase and prostaglandin inhibition.

Pub. Date : 1995 Jul

PMID : 7669618






2 Functional Relationships(s)
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1 Culture with indomethacin significantly enhanced OKT3-stimulated IFN-gamma production in both groups, whereas OKT3-stimulated IFN-gamma production was abolished with dibutyryl cAMP. Cyclic AMP interferon gamma Homo sapiens
2 IFN-gamma release from AD MNL was more sensitive to the inhibitory effects of PDE, and this may be due to increased PDE activity, or the hyperdynamic cAMP system present in atopics. Cyclic AMP interferon gamma Homo sapiens