Pub. Date : 1995 Sep
PMID : 7666790
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acute effects of troglitazone on in vivo insulin action in normal rats. | Troglitazone | insulin | Homo sapiens |
| 2 | Troglitazone is a newly developed antidiabetic agent that shows hypoglycemic effects in insulin-resistant animal models and non-insulin-dependent diabetic humans. | Troglitazone | insulin | Homo sapiens |
| 3 | At 18-pmol/kg/min insulin infusion rate, steady-state glucose disposal rate (GDR) was significantly increased during troglitazone infusion versus control vehicle infusion (162 +/- 6.1 v 142.3 +/- 4.4 mumol/kg/min, P < .02). | Troglitazone | insulin | Homo sapiens |
| 4 | At 9-pmol/kg/min insulin infusion rate, HGP was significantly decreased during troglitazone infusion as compared with control vehicle infusion (21.7 +/- 3.5 v 39.5 +/- 3.7 mumol/kg/min, P < .02). | Troglitazone | insulin | Homo sapiens |
| 5 | These results indicate that troglitazone can acutely increase in vivo insulin action in normal rats, and some possible mechanisms are discussed. | Troglitazone | insulin | Homo sapiens |