Title : Cross-resistance to camptothecin analogues in a mitoxantrone-resistant human breast carcinoma cell line is not due to DNA topoisomerase I alterations.

Pub. Date : 1995 Sep 15

PMID : 7664272






1 Functional Relationships(s)
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1 We have previously described a mitoxantrone-resistant human breast carcinoma cell line, MCF7/MX, in which resistance was associated with a defect in the energy-dependent accumulation of mitoxantrone in the absence of P-glycoprotein overexpression (M. Nakagawa et al., Cancer Res. Mitoxantrone ATP binding cassette subfamily B member 1 Homo sapiens