Title : Reversal of alcohol's effects on neurite extension and on neuronal GAP43/B50, N-myc, and c-myc protein levels by retinoic acid.

Pub. Date : 1995 May 26

PMID : 7656409






3 Functional Relationships(s)
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1 These retinoic acid-induced increases in GAP43/B50 and neurite outgrowth, and decreases in N-myc and c-myc, were reversed dose-dependently by alcohol (0-0.5%). Tretinoin MYCN proto-oncogene, bHLH transcription factor Homo sapiens
2 Conversely, the adverse effects of 0.25% alcohol on neurite extension, GAP43/B50, N-myc, and c-myc were prevented by 15 and 45 nM retinoic acid. Tretinoin MYCN proto-oncogene, bHLH transcription factor Homo sapiens
3 These results suggest that inhibition of neuronal differentiation by alcohol and prevention of such effects by retinoic acid are related to changes in GAP43/B50, N-myc and c-myc. Tretinoin MYCN proto-oncogene, bHLH transcription factor Homo sapiens