Title : Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion.

Pub. Date : 1995 Aug 25

PMID : 7650022






1 Functional Relationships(s)
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1 Taken together with previous studies, the current results suggest that during glucose-induced insulin secretion there is a shuttle operating across the mitochondrial membrane in which glucose-derived pyruvate is taken up by mitochondria and carboxylated to oxaloacetate by pyruvate carboxylase. Oxaloacetic Acid pyruvate carboxylase Homo sapiens