Title : Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction.

Pub. Date : 1995 Aug 17

PMID : 7637810






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Activation of PKB was inhibited by the phosphatidylinositol-3-OH kinase (PI(3)K) inhibitor wortmannin and by coexpression of a dominant-negative mutant of PI(3)K. PDGF receptor mutants that lack detectable associated PI(3)K activity also fail to induce PKB activation, PKB kinase activity is correlated with phosphorylation of PKB on serine. Wortmannin protein tyrosine kinase 2 beta Homo sapiens