Title : Potent inhibitors of acyl-CoA:cholesterol acyltransferase. Structure-activity relationships of novel N-(4-oxochroman-8-yl)amides.

Pub. Date : 1995 Aug 4

PMID : 7636880






1 Functional Relationships(s)
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1 Novel N-(4-oxochroman-8-yl)amide derivatives 1 were synthesized and tested for their ability to inhibit rabbit small intestinal ACAT (acyl-CoA:cholesterol acyltransferase) in vitro and to lower serum total cholesterol in cholesterol-fed rats in vivo. Cholesterol sterol O-acyltransferase 1 Oryctolagus cuniculus