Title : The relaxant action of jatrophone in rat portal vein. A comparison with protein kinase C inhibitors.

Pub. Date : 1995

PMID : 7630315






2 Functional Relationships(s)
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1 Jatrophone, staurosporine and H-7, caused graded inhibition of rat portal vein contractions induced by phorbol 12-myristate 13-acetate (PMA), noradrenaline, endothelin-1 or KCl, with IC50s of 86 nM, 13 microM, 11 microM and 9 microM, respectively. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine endothelin 1 Rattus norvegicus
2 Jatrophone, H-7 and staurosporine caused graded relaxations of preparations contracted with endothelin-1 or PMA with IC50s of 12 and > 1000 microM, 8 and 13 microM and 7 and 12 nM, respectively. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine endothelin 1 Rattus norvegicus