Title : Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 gene expression.

Pub. Date : 1995 Aug

PMID : 7623839






3 Functional Relationships(s)
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1 We show that exposure of cells to various genotoxic agents, including anticancer drugs such as mitomycin and 5-fluorouracil, results in an increase in p53 mRNA levels and in p53 promoter activation, indicating that the p53 genotoxic stress response is partly regulated at the transcriptional level. Mitomycin tumor protein p53 Homo sapiens
2 We show that exposure of cells to various genotoxic agents, including anticancer drugs such as mitomycin and 5-fluorouracil, results in an increase in p53 mRNA levels and in p53 promoter activation, indicating that the p53 genotoxic stress response is partly regulated at the transcriptional level. Mitomycin tumor protein p53 Homo sapiens
3 We show that exposure of cells to various genotoxic agents, including anticancer drugs such as mitomycin and 5-fluorouracil, results in an increase in p53 mRNA levels and in p53 promoter activation, indicating that the p53 genotoxic stress response is partly regulated at the transcriptional level. Mitomycin tumor protein p53 Homo sapiens