Title : Bicarbonate and phosphate ions protect transferrin from myeloperoxidase-mediated damage.

Pub. Date : 1995 Jul

PMID : 7616107






5 Functional Relationships(s)
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1 Exposure to hypochlorous acid (HOCl), the main product of the reaction of neutrophil myeloperoxidase (MPO), H2O2, and Cl-, reportedly decreases apotransferrin"s iron binding capacity. Iron myeloperoxidase Homo sapiens
2 Exposure to hypochlorous acid (HOCl), the main product of the reaction of neutrophil myeloperoxidase (MPO), H2O2, and Cl-, reportedly decreases apotransferrin"s iron binding capacity. Iron myeloperoxidase Homo sapiens
3 Although the MPO system decreased apotransferrin iron uptake to only 46% of the untreated apotransferrin control, apotransferrin treated in the presence of 1 mM HCO3- or H2PO4- retained 84 and 74%, respectively, of its iron binding capacity. Iron myeloperoxidase Homo sapiens
4 HCO3- and H2PO4- may protect apotransferrin from MPO-mediated oxidative damage by preventing selective oxidation of one or both iron binding sites. Iron myeloperoxidase Homo sapiens
5 This process may allow transferrin to retain its iron binding function during MPO exposure in vivo. Iron myeloperoxidase Homo sapiens