Pub. Date : 1995 Jul
PMID : 7616107
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exposure to hypochlorous acid (HOCl), the main product of the reaction of neutrophil myeloperoxidase (MPO), H2O2, and Cl-, reportedly decreases apotransferrin"s iron binding capacity. | Iron | myeloperoxidase | Homo sapiens |
| 2 | Exposure to hypochlorous acid (HOCl), the main product of the reaction of neutrophil myeloperoxidase (MPO), H2O2, and Cl-, reportedly decreases apotransferrin"s iron binding capacity. | Iron | myeloperoxidase | Homo sapiens |
| 3 | Although the MPO system decreased apotransferrin iron uptake to only 46% of the untreated apotransferrin control, apotransferrin treated in the presence of 1 mM HCO3- or H2PO4- retained 84 and 74%, respectively, of its iron binding capacity. | Iron | myeloperoxidase | Homo sapiens |
| 4 | HCO3- and H2PO4- may protect apotransferrin from MPO-mediated oxidative damage by preventing selective oxidation of one or both iron binding sites. | Iron | myeloperoxidase | Homo sapiens |
| 5 | This process may allow transferrin to retain its iron binding function during MPO exposure in vivo. | Iron | myeloperoxidase | Homo sapiens |