Title : Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface.

Pub. Date : 1995 Jul

PMID : 7615164






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Chondroitin sulfate binds to a basic surface on thrombin that is also involved in heparin interaction. Chondroitin Sulfates coagulation factor II, thrombin Homo sapiens
2 The chondroitin sulfate enhances the affinity of thrombin for thrombomodulin approximately 10- to 20-fold, making thrombomodulin a more potent inhibitor of coagulation, altering thrombin"s conformation and specificity, and accelerating thrombin inhibition by the serpin, antithrombin. Chondroitin Sulfates coagulation factor II, thrombin Homo sapiens
3 The chondroitin sulfate enhances the affinity of thrombin for thrombomodulin approximately 10- to 20-fold, making thrombomodulin a more potent inhibitor of coagulation, altering thrombin"s conformation and specificity, and accelerating thrombin inhibition by the serpin, antithrombin. Chondroitin Sulfates coagulation factor II, thrombin Homo sapiens
4 The chondroitin sulfate enhances the affinity of thrombin for thrombomodulin approximately 10- to 20-fold, making thrombomodulin a more potent inhibitor of coagulation, altering thrombin"s conformation and specificity, and accelerating thrombin inhibition by the serpin, antithrombin. Chondroitin Sulfates coagulation factor II, thrombin Homo sapiens