Title : Dihydrofolate reductase in primary brain tumors, cell cultures of central nervous system origin, and normal brain during fetal and neonatal growth.

Pub. Date : 1979 Feb

PMID : 761221






1 Functional Relationships(s)
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1 The presence of DHFR in neoplasms of central nervous system origin is relevant to the development of folate antagonists which, unlike methotrexate, can readily cross the blood-brain barrier. Folic Acid dihydrofolate reductase Rattus norvegicus