Title : MRP gene overexpression in a human doxorubicin-resistant SCLC cell line: alterations in cellular pharmacokinetics and in pattern of cross-resistance.

Pub. Date : 1995 Jul 4

PMID : 7601572






2 Functional Relationships(s)
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1 This study provides evidence that (a) altered cellular pharmacokinetics is related to MRP expression; (b) MRP-mediated phenotype is characterized by a specific pattern of cross-resistance, which does not involve taxol; and (c) verapamil may be effective in modulating the function of the MRP gene product. Paclitaxel ATP binding cassette subfamily C member 1 Homo sapiens
2 This study provides evidence that (a) altered cellular pharmacokinetics is related to MRP expression; (b) MRP-mediated phenotype is characterized by a specific pattern of cross-resistance, which does not involve taxol; and (c) verapamil may be effective in modulating the function of the MRP gene product. Paclitaxel ATP binding cassette subfamily C member 1 Homo sapiens