Pub. Date : 1995 Oct 13
PMID : 7592625
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of guanine nucleotide binding on the intrinsic tryptophan fluorescence properties of Rab5. | Guanine Nucleotides | RAB5A, member RAS oncogene family | Homo sapiens |
| 2 | These data indicate that both of Rab5"s tryptophans are brought into a more sequestered, hydrophobic environment upon conformational changes promoted by guanine nucleotide exchange. | Guanine Nucleotides | RAB5A, member RAS oncogene family | Homo sapiens |
| 3 | However, Trp114 lies within a region of Rab5 potentially related to the switch III domain unique to heterotrimeric G alpha t. Thus, changes in the fluorescence properties of Trp114 upon guanine nucleotide exchange suggest that Rab proteins may have structure-function relationships similar to those described for heterotrimeric GTP-binding proteins. | Guanine Nucleotides | RAB5A, member RAS oncogene family | Homo sapiens |