Title : Induction of kinetochore-containing micronuclei by exogenous O6-methylguanine requires conversion of the methylated base to a nucleotide.

Pub. Date : 1995

PMID : 7588648






2 Functional Relationships(s)
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1 It is shown here that the aneugenic effect of O6meG, evidenced by its ability to induce micronuclei in rodent cells, is dependent on its conversion to O6-methyl-guanosine-5"-monophosphate (O6me-5"-GMP) by hypoxanthine-guanine phosphoribosyl transferase (HPRT). O-(6)-methylguanine hypoxanthine phosphoribosyltransferase 1 Homo sapiens
2 It is shown here that the aneugenic effect of O6meG, evidenced by its ability to induce micronuclei in rodent cells, is dependent on its conversion to O6-methyl-guanosine-5"-monophosphate (O6me-5"-GMP) by hypoxanthine-guanine phosphoribosyl transferase (HPRT). O-(6)-methylguanine hypoxanthine phosphoribosyltransferase 1 Homo sapiens