Title : Control of 1,25-dihydroxyvitamin D3 receptor-mediated enhancement of osteocalcin gene transcription: effects of perturbing phosphorylation pathways by okadaic acid and staurosporine.

Pub. Date : 1995 Dec

PMID : 7588324






2 Functional Relationships(s)
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1 Vitamin D-induced transcription was assayed in transfected ROS 17/2.8 osteosarcoma cells using chloraminphenicol acetyltransferase constructs containing the vitamin D-responsive element (VDRE) at its native locus in the rat OC promoter as well as fused to a heterologous promoter. Vitamin D bone gamma-carboxyglutamate protein Rattus norvegicus
2 Both ST and OA inhibit VDRE-mediated and vitamin D-dependent enhancement of OC gene transcription as well as OC biosynthesis, as assessed by RIAs. Vitamin D bone gamma-carboxyglutamate protein Rattus norvegicus