Title : Cytochrome P450 mediated reactions studied in genetically engineered V79 Chinese hamster cells.

Pub. Date : 1995

PMID : 7581497






1 Functional Relationships(s)
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1 Most important was the finding, that human cytochrome P450 1A1 almost exclusively oxidized benzo[a]pyrene in the 7,8,9,10-position, yielding the ultimate carcinogen 7,8-dihydroxy-9,10-epoxy-7,8,9, 10-tetrahydrobenzo[a]pyrene whereas the rat cytochrome P450 1A1 oxidized benzo[]pyrene in the 4,5-position and 7,8,9,10-position. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide cytochrome P450 family 1 subfamily A member 1 Homo sapiens