Title : Arachidonic acid induces c-jun gene expression in stromal cells stimulated by interleukin-1 and tumor necrosis factor-alpha: evidence for a tyrosine-kinase-dependent process.

Pub. Date : 1995 Oct 15

PMID : 7579389






2 Functional Relationships(s)
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1 Downregulation of protein kinase C (PKC) by chronic exposure of stromal cells to the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA; 400 nmol/L) did not effect c-jun expression induced by arachidonate. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus
2 Moreover, pretreatment of cells with the PKC inhibitor, calphostin C (1 mumol/L), caused a marked decrease of c-jun expression induced by TPA, but had no influence on c-jun expression induced by arachidonate. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus