Title : Molecular genetic systems to study the role of poly(ADP-ribosyl)ation in the cellular response to DNA damage.

Pub. Date : 1995

PMID : 7578428






1 Functional Relationships(s)
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1 In these cells we observe a drastic trans-dominant inhibition of poly(ADP-ribosyl)ation which is associated with sensitization of cells to gamma-irradiation; and ii) in an attempt to specifically increase the poly(ADP-ribose) formation capacity in living cells, the hamster cell line CO60 was stably transfected to obtain constitutive overexpression of full-length human PARP. poly(adp-ribosyl) poly(ADP-ribose) polymerase 1 Homo sapiens