Pub. Date : 1995 Oct 1
PMID : 7575451
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously reported that difluoromethylornithine (DFMO), an inhibitor of polyamine biosynthesis, exerted significant beneficial effects on the lifespan and disease expression of MRL-lpr/lpr mice, which spontaneously develop a lupus-like syndrome. | Eflornithine | Fas (TNF receptor superfamily member 6) | Mus musculus |
| 2 | We previously reported that difluoromethylornithine (DFMO), an inhibitor of polyamine biosynthesis, exerted significant beneficial effects on the lifespan and disease expression of MRL-lpr/lpr mice, which spontaneously develop a lupus-like syndrome. | Eflornithine | Fas (TNF receptor superfamily member 6) | Mus musculus |
| 3 | We previously reported that difluoromethylornithine (DFMO), an inhibitor of polyamine biosynthesis, exerted significant beneficial effects on the lifespan and disease expression of MRL-lpr/lpr mice, which spontaneously develop a lupus-like syndrome. | Eflornithine | Fas (TNF receptor superfamily member 6) | Mus musculus |
| 4 | We previously reported that difluoromethylornithine (DFMO), an inhibitor of polyamine biosynthesis, exerted significant beneficial effects on the lifespan and disease expression of MRL-lpr/lpr mice, which spontaneously develop a lupus-like syndrome. | Eflornithine | Fas (TNF receptor superfamily member 6) | Mus musculus |
| 5 | Treatment of MRL-lpr/lpr mice with DFMO increased [Ca2+]i to 360 +/- 30 nM (P < 0.05). | Eflornithine | Fas (TNF receptor superfamily member 6) | Mus musculus |
| 6 | Treatment of MRL-lpr/lpr mice with DFMO increased [Ca2+]i to 360 +/- 30 nM (P < 0.05). | Eflornithine | Fas (TNF receptor superfamily member 6) | Mus musculus |
| 7 | DFMO treatment increased InsP3 levels in concanavalin A-treated MRL-lpr/lpr T-cells to 67%. | Eflornithine | Fas (TNF receptor superfamily member 6) | Mus musculus |
| 8 | DFMO treatment increased InsP3 levels in concanavalin A-treated MRL-lpr/lpr T-cells to 67%. | Eflornithine | Fas (TNF receptor superfamily member 6) | Mus musculus |
| 9 | DFMO treatment reduced tyrosine phosphorylation of p56lck of MRL-lpr/lpr mice significantly (P < 0.001). | Eflornithine | Fas (TNF receptor superfamily member 6) | Mus musculus |
| 10 | DFMO treatment reduced tyrosine phosphorylation of p56lck of MRL-lpr/lpr mice significantly (P < 0.001). | Eflornithine | Fas (TNF receptor superfamily member 6) | Mus musculus |
| 11 | These data show that DFMO treatment could alter signal-transduction pathways of splenic T-cells of MRL-lpr/lpr mice. | Eflornithine | Fas (TNF receptor superfamily member 6) | Mus musculus |
| 12 | These data show that DFMO treatment could alter signal-transduction pathways of splenic T-cells of MRL-lpr/lpr mice. | Eflornithine | Fas (TNF receptor superfamily member 6) | Mus musculus |