Title : Fungal metabolic model for human type I hereditary tyrosinaemia.

Pub. Date : 1995 Sep 26

PMID : 7568087






1 Functional Relationships(s)
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1 We report here that fahA, the gene encoding Fah in the fungus Aspergillus nidulans, encodes a polypeptide showing 47.1% identity to its human homologue, fahA disruption results in secretion of succinylacetone (a diagnostic compound for human type I tyrosinaemia) and phenylalanine toxicity. succinylacetone fumarylacetoacetate hydrolase Homo sapiens