Pub. Date : 1995 Oct
PMID : 7561521
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histamine enhances granulocyte-macrophage colony-stimulating factor and interleukin-6 production by human peripheral blood mononuclear cells. | Histamine | colony stimulating factor 2 | Homo sapiens |
| 2 | Using ELISA and radioimmunoassay kits, histamine was found to enhance the production of GM-CSF (9.6-fold) and IL-6 (8.2-fold) by mononuclear cells but not by nonadherent cells or large granular lymphocytes. | Histamine | colony stimulating factor 2 | Homo sapiens |
| 3 | Anti-GM-CSF and anti-IL-6 antibodies markedly blocked cytokine activity in CM-PBS, whereas the blocking effect in CM-histamine was moderate, indicating enhanced GM-CSF and IL-6 activity in CM-histamine. | Histamine | colony stimulating factor 2 | Homo sapiens |
| 4 | We conclude that histamine is able to activate human mononuclear cells to generate cytokines such as GM-CSF and IL-6 via H1 and H2 receptors. | Histamine | colony stimulating factor 2 | Homo sapiens |