Title : A peptide that mimics the carboxy-terminal domain of SNAP-25 blocks Ca(2+)-dependent exocytosis in chromaffin cells.

Pub. Date : 1995 Sep 18

PMID : 7556639






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 SNAP-25 occurs in neuroendocrine cells and, in analogy to its role in neurons, has been implicated in catecholamine secretion, yet the nature of the underlying mechanism remains obscure. Catecholamines synaptosome associated protein 25 Homo sapiens
2 Remarkably, a 20-mer synthetic peptide representing the sequence of the C-terminal domain of SNAP-25 blocked Ca(2+)-dependent catecholamine release with an IC50 = 20 microM. Catecholamines synaptosome associated protein 25 Homo sapiens