Title : Does P-glycoprotein play a pivotal role in the drug resistance of an MDR variant, K562/Dox?

Pub. Date : 1995 Jul-Aug

PMID : 7555211






3 Functional Relationships(s)
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1 K562/Dox displayed typical MDR features with respect to its cross-resistance to a variety of functionally and structurally unrelated compounds: vincristine (Vin), Dox, mitomycin C, reduced steady-state intracellular anthracycline accumulation, and elevated P-glycoprotein expression/mdr1 mRNA transcription/mdr1 gene amplification. 5-Bromoisatin ATP binding cassette subfamily B member 1 Homo sapiens
2 K562/Dox displayed typical MDR features with respect to its cross-resistance to a variety of functionally and structurally unrelated compounds: vincristine (Vin), Dox, mitomycin C, reduced steady-state intracellular anthracycline accumulation, and elevated P-glycoprotein expression/mdr1 mRNA transcription/mdr1 gene amplification. 5-Bromoisatin ATP binding cassette subfamily B member 1 Homo sapiens
3 K562/Dox displayed typical MDR features with respect to its cross-resistance to a variety of functionally and structurally unrelated compounds: vincristine (Vin), Dox, mitomycin C, reduced steady-state intracellular anthracycline accumulation, and elevated P-glycoprotein expression/mdr1 mRNA transcription/mdr1 gene amplification. 5-Bromoisatin ATP binding cassette subfamily B member 1 Homo sapiens