Title : Stem cell factor retards differentiation of normal human erythroid progenitor cells while stimulating proliferation.

Pub. Date : 1995 Jul 15

PMID : 7541668






2 Functional Relationships(s)
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1 Addition of SCF to the ECFC in serum-free liquid culture, together with erythropoietin (EP) and insulin-like growth factor 1 (IGF-1), resulted in a marked increase in DNA synthesis, associated with a delayed peak in cellular benzidine positivity and a delayed incorporation of 59Fe into hemoglobin compared with cultures without SCF. benzidine KIT ligand Homo sapiens
2 In the presence of SCF, the number of ECFC was greatly expanded during this culture period, and total production of benzidine-positive cells plus hemoglobin synthesis were ultimately increased. benzidine KIT ligand Homo sapiens