Title : Inhibition of leukotriene production by FK506 in rat basophilic leukemia-1 cells.

Pub. Date : 1995 Mar

PMID : 7538218






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We investigated the inhibitory action of FK506 (0.0005-5 micrograms/ml) on the metabolism of arachidonate 5-lipoxygenase in rat basophilic leukemia-1 cells. Tacrolimus arachidonate 5-lipoxygenase Rattus norvegicus
2 These results indicate that FK506 inhibits the production of peptide LTs, LTB4 and 5-HETE by inhibiting 5-lipoxygenase activity in intact cells. Tacrolimus arachidonate 5-lipoxygenase Rattus norvegicus