Title : Inhibitors of protein and RNA synthesis block the cytotoxic effects of non-steroidal antiestrogens.

Pub. Date : 1995 Apr 28

PMID : 7537976






1 Functional Relationships(s)
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1 In the case of K36 and EL4 cells, inclusion of tamoxifen or clomiphene in the culture medium regularly caused the viable call count to fall below 20-30% of control in 36-48 h. Under these conditions, the addition of inhibitors of protein or RNA synthesis consistently increased viable cell count in a dose-dependent manner. Clomiphene epilepsy 4 Mus musculus