Pub. Date : 1994 Nov
PMID : 7537937
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of R59022, an inhibitor of diacylglycerol kinase, on IgE-mediated histamine release from human lung mast cells and basophils. | Histamine | immunoglobulin heavy constant epsilon | Homo sapiens |
| 2 | At 1 microM the drug increased the IgE-dependent release of histamine from human basophils from 19 +/- 5% to 60 +/- 13% (n = 5, p < 0.01). | Histamine | immunoglobulin heavy constant epsilon | Homo sapiens |
| 3 | As anticipated there was a strong negative correlation (r = 0.764, p < 0.05) between anti-IgE-induced histamine release and the percentage enhancement in the presence of 10 microM R59022. | Histamine | immunoglobulin heavy constant epsilon | Homo sapiens |
| 4 | The data suggest that the R59022 increases the release of histamine induced by anti-IgE in human basophils but not in human lung mast cells. | Histamine | immunoglobulin heavy constant epsilon | Homo sapiens |