Title : Cyclosporin A inhibits nitric oxide synthase induction in vascular smooth muscle cells.

Pub. Date : 1995 Apr

PMID : 7536714






2 Functional Relationships(s)
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1 A combination of interleukin-1 alpha (100 U/mL) and tumor necrosis factor--alpha (5000 U/mL) induced accumulation of nitrite/nitrate, the stable end products of nitric oxide, in culture media within 48 hours. Nitrates tumor necrosis factor Rattus norvegicus
2 Induction of nitrite/nitrate production by the combination of tumor necrosis factor-alpha and bacterial lipopolysaccharide or that of interleukin-1 alpha and interferon gamma (100 U/mL) was also inhibited by cyclosporin A cotreatment. Nitrates tumor necrosis factor Rattus norvegicus