Title : Cytokine-mediated expansion of 5-FU-resistant peripheral blood stem cells.

Pub. Date : 1995 Apr

PMID : 7534710






2 Functional Relationships(s)
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1 We found a significant increase in the proportion of CD34+ cells in the PBSC fraction resistant to 25 micrograms/mL 5-FU after 7-day incubation with IL-1 plus IL-3 plus SCF as compared with the untreated fraction (p = 0.011). Fluorouracil interleukin 1 alpha Homo sapiens
2 We also showed that 5-FU-resistant PBSC have a greater capacity for expansion of IL-1/IL-3/SCF-responsive immature progenitors (p = 0.05), amplification of IL-3 plus GM-CSF responsive progenitors (p = 0.01), and production of committed single growth factor-responsive (granulocyte-macrophage colony-stimulating factor [GM-CSF]) precursors (p = 0.01) than the untreated PBSC. Fluorouracil interleukin 1 alpha Homo sapiens