Pub. Date : 1995 Feb
PMID : 7533090
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased expression of FKBP12 resulted in increased sensitivity to FK506 and rapamycin, as measured by inhibition of calcineurin activity and p70 S6 kinase activity, respectively. | Sirolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 2 | Two distinct point mutations in FKBP12, one altering a hydrophobic residue within the drug-binding pocket and the other changing a charged surface residue of FKBP12, abrogated its ability to mediate sensitivity to FK506 and rapamycin. | Sirolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 3 | Two distinct point mutations in FKBP12, one altering a hydrophobic residue within the drug-binding pocket and the other changing a charged surface residue of FKBP12, abrogated its ability to mediate sensitivity to FK506 and rapamycin. | Sirolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |