Title : The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells.

Pub. Date : 1995 Feb 15

PMID : 7530743






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The IC50 value for FK506 inhibition of IgE activation-induced transcripts for TNF-alpha decreased from 40 nM in vector control cells to 10 nM in FKBP12 transfectants. Tacrolimus tumor necrosis factor Mus musculus
2 Thus, FKBP12 is the dominant cytosolic protein that mediates FK506 inhibition of TNF-alpha and IL-6 transcripts. Tacrolimus tumor necrosis factor Mus musculus