Pub. Date : 1995 Feb 15
PMID : 7530742
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ET-1 induced a very rapid (< or = 1 min) and dose-dependent release of histamine and serotonin from BMMC cultured in the presence of both IL-3 and IL-4. | Histamine | interleukin 4 | Mus musculus |
| 2 | In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4. | Histamine | interleukin 4 | Mus musculus |