Title : FK506, an immunosuppressant, partially inhibits interleukin 6 production by adherent rheumatoid synovial cells.

Pub. Date : 1994 Sep

PMID : 7528280






6 Functional Relationships(s)
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1 FK506, an immunosuppressant, partially inhibits interleukin 6 production by adherent rheumatoid synovial cells. Tacrolimus interleukin 6 Homo sapiens
2 OBJECTIVE: To investigate the effect of a new immunosuppressant, FK506, on interleukin 6 (IL-6) production by freshly prepared rheumatoid synovial cells. Tacrolimus interleukin 6 Homo sapiens
3 OBJECTIVE: To investigate the effect of a new immunosuppressant, FK506, on interleukin 6 (IL-6) production by freshly prepared rheumatoid synovial cells. Tacrolimus interleukin 6 Homo sapiens
4 This spontaneous production of IL-6 was significantly inhibited by FK506 at the concentration of 10(-8) to 10(-6) M in a dose dependent manner. Tacrolimus interleukin 6 Homo sapiens
5 In the preincubation study, FK506 required more than 12 h to inhibit IL-6 production by synovial cells. Tacrolimus interleukin 6 Homo sapiens
6 CONCLUSION: These results suggest that FK506 may be beneficial for patients with RA via inhibiting IL-6 production in inflammatory joints. Tacrolimus interleukin 6 Homo sapiens