Pub. Date : 1994 Sep
PMID : 7528280
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FK506, an immunosuppressant, partially inhibits interleukin 6 production by adherent rheumatoid synovial cells. | Tacrolimus | interleukin 6 | Homo sapiens |
| 2 | OBJECTIVE: To investigate the effect of a new immunosuppressant, FK506, on interleukin 6 (IL-6) production by freshly prepared rheumatoid synovial cells. | Tacrolimus | interleukin 6 | Homo sapiens |
| 3 | OBJECTIVE: To investigate the effect of a new immunosuppressant, FK506, on interleukin 6 (IL-6) production by freshly prepared rheumatoid synovial cells. | Tacrolimus | interleukin 6 | Homo sapiens |
| 4 | This spontaneous production of IL-6 was significantly inhibited by FK506 at the concentration of 10(-8) to 10(-6) M in a dose dependent manner. | Tacrolimus | interleukin 6 | Homo sapiens |
| 5 | In the preincubation study, FK506 required more than 12 h to inhibit IL-6 production by synovial cells. | Tacrolimus | interleukin 6 | Homo sapiens |
| 6 | CONCLUSION: These results suggest that FK506 may be beneficial for patients with RA via inhibiting IL-6 production in inflammatory joints. | Tacrolimus | interleukin 6 | Homo sapiens |