Pub. Date : 1994 Nov 30
PMID : 7528014
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP2A5-mediated coumarin 7-hydroxylase (COH) activity was retained in simple culture conditions for at least 96 hours and the activity was inducible up to 33-fold by phenobarbital (PB). | Phenobarbital | cytochrome P450, family 2, subfamily a, polypeptide 5 | Mus musculus |
| 2 | CYP2A5-mediated coumarin 7-hydroxylase (COH) activity was retained in simple culture conditions for at least 96 hours and the activity was inducible up to 33-fold by phenobarbital (PB). | Phenobarbital | cytochrome P450, family 2, subfamily a, polypeptide 5 | Mus musculus |
| 3 | CYP2A5-mediated coumarin 7-hydroxylase (COH) activity was retained in simple culture conditions for at least 96 hours and the activity was inducible up to 33-fold by phenobarbital (PB). | Phenobarbital | cytochrome P450, family 2, subfamily a, polypeptide 5 | Mus musculus |
| 4 | CYP2A5-mediated coumarin 7-hydroxylase (COH) activity was retained in simple culture conditions for at least 96 hours and the activity was inducible up to 33-fold by phenobarbital (PB). | Phenobarbital | cytochrome P450, family 2, subfamily a, polypeptide 5 | Mus musculus |
| 5 | CYP2A5-mediated coumarin 7-hydroxylase (COH) activity was retained in simple culture conditions for at least 96 hours and the activity was inducible up to 33-fold by phenobarbital (PB). | Phenobarbital | cytochrome P450, family 2, subfamily a, polypeptide 5 | Mus musculus |
| 6 | CYP2A5-mediated coumarin 7-hydroxylase (COH) activity was retained in simple culture conditions for at least 96 hours and the activity was inducible up to 33-fold by phenobarbital (PB). | Phenobarbital | cytochrome P450, family 2, subfamily a, polypeptide 5 | Mus musculus |
| 7 | The constitutive activity and inducibility of COH was totally blocked by treatment of hepatocytes with actinomycin D, and short initial treatment with cycloheximide caused superinducibility when co-administered with PB. | Phenobarbital | cytochrome P450, family 2, subfamily a, polypeptide 5 | Mus musculus |
| 8 | Administration of dibutyryl cAMP, forskolin, and 3-isobutyl-1-methylxanthine (IBMX) enhanced both basal and PB-induced COH activities and CYP2A5 mRNA levels, indicating that cAMP plays a major role in CYP2A5 expression. | Phenobarbital | cytochrome P450, family 2, subfamily a, polypeptide 5 | Mus musculus |
| 9 | Administration of dibutyryl cAMP, forskolin, and 3-isobutyl-1-methylxanthine (IBMX) enhanced both basal and PB-induced COH activities and CYP2A5 mRNA levels, indicating that cAMP plays a major role in CYP2A5 expression. | Phenobarbital | cytochrome P450, family 2, subfamily a, polypeptide 5 | Mus musculus |
| 10 | Administration of dibutyryl cAMP, forskolin, and 3-isobutyl-1-methylxanthine (IBMX) enhanced both basal and PB-induced COH activities and CYP2A5 mRNA levels, indicating that cAMP plays a major role in CYP2A5 expression. | Phenobarbital | cytochrome P450, family 2, subfamily a, polypeptide 5 | Mus musculus |