Title : Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

Pub. Date : 1994 Nov 22

PMID : 7526398






1 Functional Relationships(s)
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1 We include a redox-regulatory mechanism(s) in this common pathway to account for the previously demonstrated redox regulation of NF-kappa B activation in Jurkat cells (in which oxidants don"t activate NF-kappa B); we put tyrosine phosphorylation in the common pathway by showing that kinase activity (inhibitable by herbimycin A and tyrphostin 47) is required for NF-kappa B activation by all stimuli tested in both cell lines. Tyrphostins nuclear factor kappa B subunit 1 Homo sapiens