Pub. Date : 1994 Aug
PMID : 7522191
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study we found that most of the vimentin of undifferentiated HL60 and cells induced to differentiate either along the monocytoid pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA) or along the granulocytic pathway by retinoic acid was soluble in a buffer containing 1% Triton X-100/0.6 mol/l KCl in which the intermediate filament proteins usually are not soluble. | Tetradecanoylphorbol Acetate | vimentin | Homo sapiens |
| 2 | In this study we found that most of the vimentin of undifferentiated HL60 and cells induced to differentiate either along the monocytoid pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA) or along the granulocytic pathway by retinoic acid was soluble in a buffer containing 1% Triton X-100/0.6 mol/l KCl in which the intermediate filament proteins usually are not soluble. | Tetradecanoylphorbol Acetate | vimentin | Homo sapiens |
| 3 | The distribution of both forms of vimentin changed during induction of differentiation by TPA and after 24 h the Mr 54,000 species was predominant. | Tetradecanoylphorbol Acetate | vimentin | Homo sapiens |
| 4 | After an additional 24 h exposure to TPA the relative levels of the two forms of vimentin approached equivalence and a high level of vimentin degradation products was seen. | Tetradecanoylphorbol Acetate | vimentin | Homo sapiens |
| 5 | After an additional 24 h exposure to TPA the relative levels of the two forms of vimentin approached equivalence and a high level of vimentin degradation products was seen. | Tetradecanoylphorbol Acetate | vimentin | Homo sapiens |
| 6 | These results suggest that TPA may increase vimentin degradation along a pathway that has a Mr 54,000 intermediate. | Tetradecanoylphorbol Acetate | vimentin | Homo sapiens |