Title : Mutagenesis resulting from DNA damage by lipid peroxidation in the supF gene of Escherichia coli.

Pub. Date : 1994 Sep

PMID : 7520993






1 Functional Relationships(s)
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1 In vitro incubation of rat microsomal lipids with NADPH and Fe3+ in the presence of cytochrome P450 reductase produces lesions in double-stranded pZ189 plasmid DNA, the mutagenic potential of which was analyzed after transfection into Escherichia coli host cells that had been induced for SOS functions by ultraviolet irradiation. NADP cytochrome p450 oxidoreductase Rattus norvegicus