Pub. Date : 1994 Jul 15
PMID : 7517419
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TNF-alpha associated with fibronectin enhances phorbol myristate acetate- or antigen-mediated integrin-dependent adhesion of CD4+ T cells via protein tyrosine phosphorylation. | Tetradecanoylphorbol Acetate | tumor necrosis factor | Rattus norvegicus |
| 2 | A brief exposure of CD4+ cells to low dosages of soluble TNF-alpha or of FN- or laminin-bound TNF-alpha synergized with PMA to enhance the integrin-mediated binding of CD4+ cells to these immobilized ECM moieties. | Tetradecanoylphorbol Acetate | tumor necrosis factor | Rattus norvegicus |
| 3 | A brief exposure of CD4+ cells to low dosages of soluble TNF-alpha or of FN- or laminin-bound TNF-alpha synergized with PMA to enhance the integrin-mediated binding of CD4+ cells to these immobilized ECM moieties. | Tetradecanoylphorbol Acetate | tumor necrosis factor | Rattus norvegicus |
| 4 | TNF-alpha-enhanced adhesion of CD4+ cells did not delay or inhibit the subsequent detachment of the cells from the substrate, and adhesion was increased provided the cells were treated with TNF-alpha immediately after their exposure to PMA. | Tetradecanoylphorbol Acetate | tumor necrosis factor | Rattus norvegicus |
| 5 | TNF-alpha-enhanced adhesion of CD4+ cells did not delay or inhibit the subsequent detachment of the cells from the substrate, and adhesion was increased provided the cells were treated with TNF-alpha immediately after their exposure to PMA. | Tetradecanoylphorbol Acetate | tumor necrosis factor | Rattus norvegicus |
| 6 | Soluble, and to a greater extent FN-bound, TNF-alpha synergizes with PMA to intensify protein tyrosine phosphorylation in FN-bound CD4+ cells, and this effect of TNF-alpha was inhibited by inhibitors of tyrosine kinase. | Tetradecanoylphorbol Acetate | tumor necrosis factor | Rattus norvegicus |