Pub. Date : 1994 Feb
PMID : 7515369
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We characterized the potency, efficacy and time course of NG-monomethyl-l-arginine (l-NMMA) as an inhibitor of bradykinin-mediated, endothelium-dependent dilation using the human hand-vein compliance technique. | omega-N-Methylarginine | kininogen 1 | Homo sapiens |
| 2 | We characterized the potency, efficacy and time course of NG-monomethyl-l-arginine (l-NMMA) as an inhibitor of bradykinin-mediated, endothelium-dependent dilation using the human hand-vein compliance technique. | omega-N-Methylarginine | kininogen 1 | Homo sapiens |
| 3 | We also compared the efficacy of l-NMMA with methylene blue, an inhibitor of guanylate cyclase, in blocking bradykinin-mediated vasodilation. | omega-N-Methylarginine | kininogen 1 | Homo sapiens |
| 4 | l-NMMA potently inhibited bradykinin-induced venodilation with a log ED50 of 3.74 +/- 0.52 (geometric mean of 5.5 micrograms/min). | omega-N-Methylarginine | kininogen 1 | Homo sapiens |
| 5 | l-NMMA (25 micrograms/min) decreased bradykinin"s maximal venodilatory response from 90 +/- 22% to 39 +/- 15% (p < 0.05). | omega-N-Methylarginine | kininogen 1 | Homo sapiens |
| 6 | Complete recovery of bradykinin venodilation was obtained within 155 minutes after stopping l-NMMA infusion, indicating that its effects were reversible. | omega-N-Methylarginine | kininogen 1 | Homo sapiens |
| 7 | In another set of experiments we compared the efficacy of methylene blue to l-NMMA; methylene blue decreased bradykinin-mediated venodilatory response to 53 +/- 17%; when l-NMMA was added, the response was further decreased to 32 +/- 9% (p < 0.002). | omega-N-Methylarginine | kininogen 1 | Homo sapiens |