Pub. Date : 1994 Apr
PMID : 7513451
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Indeed, Kepone treatment actively suppressed induction of 2B1 and 2B2 mRNAs in hepatocytes cotreated with phenobarbital. | Phenobarbital | UDP glucuronosyltransferase family 2 member B17 | Rattus norvegicus |
| 2 | Treatment with chloral hydrate (3 x 10(-3) M), like Kepone (10(-5) M), suppressed 2B1/2 mRNA induction following phenobarbital (10(-4) M) treatment, while Kepone alcohol (10(-5) M), which is not a gem-diol, produced less suppression. | Phenobarbital | UDP glucuronosyltransferase family 2 member B17 | Rattus norvegicus |
| 3 | Our results suggest that selective induction by Kepone of 2B2 is unlikely related to its effects as a weak classical estrogen, while the ability of Kepone to suppress induction of 2B1 and 2B2 by PB may be related to its properties as a gem-diol. | Phenobarbital | UDP glucuronosyltransferase family 2 member B17 | Rattus norvegicus |