Title : N omega-nitro-L-arginine inhibits vasodilations and elevations of both cyclic AMP and cyclic GMP levels in rat aorta induced by calcitonin gene-related peptide (CGRP).

Pub. Date : 1994 Feb

PMID : 7513384






5 Functional Relationships(s)
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1 N omega-nitro-L-arginine inhibits vasodilations and elevations of both cyclic AMP and cyclic GMP levels in rat aorta induced by calcitonin gene-related peptide (CGRP). Nitroarginine calcitonin-related polypeptide alpha Rattus norvegicus
2 N omega-nitro-L-arginine inhibits vasodilations and elevations of both cyclic AMP and cyclic GMP levels in rat aorta induced by calcitonin gene-related peptide (CGRP). Nitroarginine calcitonin-related polypeptide alpha Rattus norvegicus
3 L-NNA (30 microM, 15 min) inhibited by 84, 76 and 73% the relaxations induced by rCGRP at 1, 10 and 100 nM, respectively. Nitroarginine calcitonin-related polypeptide alpha Rattus norvegicus
4 Addition of L-arginine (3 mM) 5 min before L-NNA completely prevented the L-NNA-inhibition of CGRP-induced relaxations. Nitroarginine calcitonin-related polypeptide alpha Rattus norvegicus
5 L-NNA (30 microM, 15 min) also inhibited the elevations of both cyclic AMP and cyclic GMP levels caused by CGRP (100 nM). Nitroarginine calcitonin-related polypeptide alpha Rattus norvegicus