Title : In vitro and in vivo effects of granulocyte colony-stimulating factor on neutrophils in glycogen storage disease type 1B: granulocyte colony-stimulating factor therapy corrects the neutropenia and the defects in respiratory burst activity and Ca2+ mobilization.

Pub. Date : 1994 Jan

PMID : 7510873






2 Functional Relationships(s)
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1 In vivo administration of G-CSF increased f-Met-Leu-Phe-triggered Ca2+ mobilization by neutrophils to 43% of control by mo 1 of G-CSF therapy and to 93% of control by mo 4, thus paralleling the improvements in O2- generation. N-Formylmethionine Leucyl-Phenylalanine colony stimulating factor 3 Homo sapiens
2 In vivo administration of G-CSF increased f-Met-Leu-Phe-triggered Ca2+ mobilization by neutrophils to 43% of control by mo 1 of G-CSF therapy and to 93% of control by mo 4, thus paralleling the improvements in O2- generation. N-Formylmethionine Leucyl-Phenylalanine colony stimulating factor 3 Homo sapiens