Title : The metabolism of endothelin-1 and big endothelin-1 by the isolated perfused kidney of the rabbit.

Pub. Date : 1993

PMID : 7510001






3 Functional Relationships(s)
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1 Phosphoramidon (10 microM) infused TK blocked (92 +/- 1% inhibition) the renal responses to bET-1 and reduced the overflow of ET-1-like material onto the tissues without affecting ET-1-induced renal vasoconstriction. phosphoramidon endothelin-1 Oryctolagus cuniculus
2 Phosphoramidon (10 microM) infused TK blocked (92 +/- 1% inhibition) the renal responses to bET-1 and reduced the overflow of ET-1-like material onto the tissues without affecting ET-1-induced renal vasoconstriction. phosphoramidon endothelin-1 Oryctolagus cuniculus
3 Incubation of bET-1 with rabbit renal cortical microsomes (100 micrograms protein) resulted in the generation of ET-1-like activity, as assessed by bioassay, which was inhibited by phosphoramidon (10 microM). phosphoramidon endothelin-1 Oryctolagus cuniculus